visfatin level in patients with colorectal adenoma

نویسندگان

mohammad sadegh fazeli department of surgery, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

mohammad reza keramati department of surgery, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

azam rahimi department of surgery, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

alireza kazemeini department of surgery, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)

چکیده

background: visfatin is an adipocytokine secreted by visceral adipose tissue. it has been shown that adipocytokines may contribute to the induction of carcinogens and progression of tumors. previously, we found a significant increase in the visfatin serum level in colorectal cancer patients. herein, we investigated if this cytokine increases in patients with colorectal adenoma as a precursor of colorectal cancer.   methods: in this case-control analytic study, a total of 34 patients diagnosed with colorectal adenoma and 35 disease-free controls were included. adenomas were also categorized based on their location within the colon. visfatin serum levels were measured in all cases and controls using enzyme-linked immunosorbent assay kits. in order to compare visfatin levels between groups a two-tailed t-test was considered. pearson correlation was also used to assess the relationship between visfatin levels and other measured variables.   results: patients included 18 male (53%) and 16 female (47%) with a mean±sd age of 48.3±10.96 years and controls were 18 male (51%) and 17 female (49%) with a mean±sd age of 51.6±12.52 years. there were no significant difference in terms of the visfatin level between the two groups (6.7±3.01 ng/ml for patients and 6.8±2.49 ng/ml for controls, p>0.05). except for a significant correlation between the bmi and visfatin level (p=0.041), no other correlation was detected. we found no significant difference between the levels of visfatin in each location of adenoma comparing the healthy controls (p>0.05 in all comparisons). there was no statistical difference between the locations groups in terms of visfatin level as well (p>0.05).   conclusion: visfatin serum level does not significantly increase in patients with colorectal adenoma. site of adenoma within the colon or rectum does not seem to play an important role in this regard as well.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Visfatin level in patients with colorectal adenoma

Background: Visfatin is an adipocytokine secreted by visceral adipose tissue. It has been shown that adipocytokines may contribute to the induction of carcinogens and progression of tumors. Previously, we found a significant increase in the visfatin serum level in colorectal cancer patients. Herein, we investigated if this cytokine increases in patients with colorectal adenoma as a precursor of...

متن کامل

Visfatin level in patients with colorectal adenoma

BACKGROUND Visfatin is an adipocytokine secreted by visceral adipose tissue. It has been shown that adipocytokines may contribute to the induction of carcinogens and progression of tumors. Previously, we found a significant increase in the visfatin serum level in colorectal cancer patients. Herein, we investigated if this cytokine increases in patients with colorectal adenoma as a precursor of ...

متن کامل

Circulating Serum Level of Visfatin in Patients with Endometrial Cancer

Obesity is a well-known factor that leads to many diseases including endometrial cancer. The adipose tissue is a heterogeneous organ of internal secretion. Visfatin is a newly discovered protein produced by fat tissues. The purpose of this work was to evaluate serum level concentrations of visfatin in patients with endometrial cancer based on clinical progression and histopathological tumor dif...

متن کامل

Investigating the CTGF mRNA Expression Level in Patients with Colorectal Cancer

Background: The Connective Tissue Growth Factor (CTGF) gene encoding an extracellular matrix (ECM)-associated protein and as a member of the CCN family of proteins plays a major role in fibrosis, inflammation and connective tissue remodeling in a variety of diseases including cancer. The CCN proteins are multifunctional and are involved in cell proliferation, adhesion and cell development durin...

متن کامل

miR-194 as a predictor for adenoma recurrence in patients with advanced colorectal adenoma after polypectomy.

microRNAs (miRNA) are promising predictors in colorectal cancer (CRC). We investigated whether miRNAs could predict adenoma recurrence in patients with advanced colorectal adenoma (ACRA) after polypectomy. miRNA expression profiling was performed by miRNA microarray to identify recurrence-related miRNAs. Candidate miRNAs extracted from formalin-fixed paraffin-embedded blocks of patients with AC...

متن کامل

Allopurinol in subjects with colorectal adenoma--response.

We thank de Boer and vanBodegraven for their interest in our trial (1) and the important considerations about the potential use of allopurinol for the prevention of colorectal cancer (CRC) in subjects with inflammatory bowel disease (IBD). Allopurinol has been used in the treatment of IBD for several years, and recent data (2, 3) further underline the efficacy of this drug to increase the compl...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۳۰، شماره ۱، صفحات ۷۳-۷۶

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023